Article

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14

2023-03-16

Abstract excerpt

Chemical modification of RNAs is important for post-transcriptional gene regulation. The METTL3-METTL14 complex generates most N 6 -methyladenosine (m 6 A) modifications in mRNAs, and dysregulated methyltransferase expression has been linked to numerous cancers. Here we show that changes in m 6 A modification location can impact oncogenesis. A gain-of-function missense mutation found in cancer patients, METTL14...

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Literature Corpus work: d6caaa4d-cc4a-54b5-8043-2fa25f0a48d3
DOI: 10.1101/2023.03.16.532618

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