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Article

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.

The Journal of biological chemistry - 1 Sept 2017

Xu Luang, Liu Xinyu, Sheng Na, Oo Kyaw Soe, Liang Junxin, Chionh Yok Hian, Xu Juan, Ye Fuzhou, Gao Yong-Gui, Dedon Peter C, Fu Xin-Yuan

Abstract excerpt

Chemical RNA modifications are central features of epitranscriptomics, highlighted by the discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA modifications in normal physiology and disease. Despite a resurgent interest in these modifications, the biochemistry of 3-methylcytidine (m3C) formation in mammalian RNAs is still poorly understood. However, the recent discovery of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28655767
DOI: 10.1074/jbc.M117.798298
PMCID: PMC5582859

Genes

METTL8
METTL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.PMID 28655767Read ↗

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