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Article

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.

Molecular cell - 21 Jul 2016

Wang Ping, Doxtader Katelyn A, Nam Yunsun

Abstract excerpt

N(6)-methyladenosine (m(6)A) is a prevalent, reversible chemical modification of functional RNAs and is important for central events in biology. The core m(6)A writers are Mettl3 and Mettl14, which both contain methyltransferase domains. How Mettl3 and Mettl14 cooperate to catalyze methylation of adenosines has remained elusive. We present crystal structures of the complex of Mettl3/Mettl14 methyltransferase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27373337
DOI: 10.1016/j.molcel.2016.05.041
PMCID: PMC4958592

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