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Article

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

Science advances - 20 Dec 2024

Zhang Chi, Scott Robyn L, Tunes Luiza, Hsieh Meng-Hsiung, Wang Ping, Kumar Ashwani, Khadgi Brijesh B, Yang Yen-Yu, Doxtader Lacy Katelyn A, Herrell Emily, Zhang Xunzhi, Evers Bret, Wang Yinsheng, Xing Chao, Zhu Hao, Nam Yunsun

Abstract excerpt

Chemical modification of RNAs is important for posttranscriptional gene regulation. The METTL3-METTL14 complex generates most N6-methyladenosine (m6A) modifications in messenger RNAs (mRNAs), and dysregulated methyltransferase expression has been linked to cancers. Here we show that a changed sequence context for m6A can promote oncogenesis. A gain-of-function missense mutation from patients with cancer,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39705353
DOI: 10.1126/sciadv.ads4750
PMCID: PMC11661435

Genes

METTL14
METTL3
ALKBH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.PMID 39705353Read ↗

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14Semantic proximity Read ↗

A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.Semantic proximity Read ↗

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Structural insights into the molecular mechanism of the m6A writer complexSemantic proximity Read ↗

Mutations in m6A consensus motifs are suppressed in the m6A modified genes in human cancer cells.Semantic proximity Read ↗

Epigenetic Regulation of m6A Modifications in Human CancerSemantic proximity Read ↗

Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensingSemantic proximity Read ↗

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METTL4 catalyzes m6Am methylation in <i>U2 snRNA</i> to regulate pre-mRNA splicingSemantic proximity Read ↗

N6-Methyladenosine Role in Cancer: Learning from AMLSemantic proximity Read ↗

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