Article
A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.
Cell reports - 25 Jul 2023
Miyake Kotaro, Costa Cruz Pedro Henrique, Nagatomo Izumi, Kato Yuki, Motooka Daisuke, Satoh Shingo, Adachi Yuichi, Takeda Yoshito, Kawahara Yukio, Kumanogoh Atsushi
Abstract excerpt
The methyltransferase-like 3 (METTL3)-/METTL14-containing complex predominantly catalyzes N6-methyladenosine (m6A) modification, which affects mRNA stability. Although the METTL14 R298P mutation is found in multiple cancer types, its biological effects are not completely understood. Here, we show that the heterozygous R298P mutation promotes cancer cell proliferation, whereas the homozygous mutation reduces...
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