Genomic Instability Evolutionary Footprints on Human Health: Driving Forces or Side Effects?

doi:10.3390/ijms241411437

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Article

Genomic Instability Evolutionary Footprints on Human Health: Driving Forces or Side Effects?

International journal of molecular sciences - 14 Jul 2023

Veschetti Laura, Treccani Mirko, De Tomi Elisa, Malerba Giovanni

Abstract excerpt

In this work, we propose a comprehensive perspective on genomic instability comprising not only the accumulation of mutations but also telomeric shortening, epigenetic alterations and other mechanisms that could contribute to genomic information conservation or corruption. First, we present mechanisms playing a role in genomic instability across the kingdoms of life. Then, we explore the impact of genomic...

Topics

Humans
Genomic Instability
Mutation
Aging
Longevity
Drug-Related Side Effects and Adverse Reactions
DNA Repair

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PMID: 37511197
DOI: 10.3390/ijms241411437
PMCID: PMC10380557

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