Genome instability and aging: Cause or effect?

Abstract excerpt

Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal lineages, such as tumors, normal tissues have thus far not been amenable to mutation analysis except for the largest type of mutations: chromosomal aberrations. This is because mutations are random events and, therefore...

Identifiers and source

Literature Corpus work

d00086c8-d20a-5f64-bdff-e5f4814d2d16

DOI

10.1016/j.tma.2017.09.003