Article
In memoriam Bernard Strehler--genomic instability in ageing: a persistent challenge.
Mechanisms of ageing and development - 30 Apr 2002
Bürkle Alexander
Abstract excerpt
Genomic instability comprises a broad spectrum of mutational alterations in the genome, such as point mutations in DNA, microsatellite expansions or contractions, amplifications and deletions of DNA sequences, gene rearrangements and structural or numerical chromosomal aberrations. A substantial body of data demonstrates an increase of genomic instability during normal ageing. This includes cytogenetic changes;...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.