Article

scPharm: identifying pharmacological subpopulations of single cells for precision medicine in cancers

2023-12-12

Abstract excerpt

Intratumour heterogeneity is a major challenge that limits the effectiveness of anticancer therapies, thus compromising treatment outcomes. Single-cell RNA sequencing (scRNA-seq) technology offers a means to capture gene expression profiles at a single-cell resolution, while drug perturbation experiments yield valuable pharmacological data at the bulk cell level. Here, we introduce “scPharm”, a computational frame...

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Literature Corpus work: d64cbc22-399d-5487-a6de-0938f8478943
DOI: 10.1101/2023.12.11.571182

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