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Application of single-cell and spatial omics in deciphering cellular hallmarks of cancer drug response and resistance

2 Jul 2025

Abstract excerpt

Drug resistance poses a significant challenge in cancer therapy, contributing to rapid recurrence, disease progression, and high patient mortality. Despite its critical impact, few reliable predictors for cancer drug response or failure have been established for clinical application. Tumor heterogeneity and the tumor microenvironment (TME) are pivotal factors influencing cancer drug efficacy and resistance. Tumor...

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PMID: 40605007
DOI: 10.1186/s13045-025-01722-1

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