Article

Predicting Pre-treatment Resistance or Post-treatment Effect? A Systematic Benchmarking of Single-Cell Drug Response Models

2026-04-14

Abstract excerpt

Intratumoral heterogeneity drives variable drug responses in cancer. Single-cell RNA sequencing (scRNA-seq) enables characterization of such heterogeneity and prediction of drug response at single-cell resolution. Accordingly, various computational models have been developed to infer drug response from scRNA-seq data. However, their performance, robustness, and generalizability across different biological contexts...

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Literature Corpus work: f106e2dc-9441-5051-81f2-26f88d56561a
DOI: 10.64898/2026.04.10.717709

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