Article

Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq

2021-04-09

Abstract excerpt

We present Beyondcell ( https://gitlab.com/bu_cnio/beyondcell/ ), a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clusters (TCs) within cellular populations. Additionally, Beyondcell determine...

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Literature Corpus work: b7dd91f0-56b7-522d-9fd7-919bfa125224
DOI: 10.1101/2021.04.08.438954

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