Article

Phenotypic deconvolution in heterogeneous cancer cell populations using drug screening data

2022-01-20

Abstract excerpt

<h4>Summary</h4> Tumor heterogeneity is an important driver of treatment failure in cancer since therapies often select for drug-tolerant or drug-resistant cellular subpopulations that drive tumor growth and recurrence. Profiling the drug-response heterogeneity of tumor samples using traditional genomic deconvolution methods has yielded limited results, due in part to the imperfect mapping between genomic variati...

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Literature Corpus work: d0fd7d79-1e1e-58b3-b52b-6b8582c7e97a
DOI: 10.1101/2022.01.17.476604

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