Article

A single-cell atlas of breast cancer cell lines to study tumour heterogeneity and drug response

2021-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer patient stratification is mainly driven by tumour receptor status and histological grading and subtyping, with about twenty percent of patients for which absence of any actionable biomarkers results in no clear therapeutic intervention. Cancer cells within the same tumour have heterogeneous phenotypes and exhibit dynamic plasticity. However, how to evaluate such heterogeneity and i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7e4bee7-d3c3-5e6b-abad-3bd910456f4a
DOI: 10.1101/2021.03.02.433590

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single-cell atlas of breast cancer cell lines to study tumour heterogeneity and drug responseDOI 10.1101/2021.03.02.433590Read

Single‐cell transcriptional atlas of human breast cancers and model systemsSemantic proximity Read

The Breast Cancer Single-Cell Atlas: Defining cellular heterogeneity within model cell lines and primary tumors to inform disease subtype, stemness, and treatment optionsSemantic proximity Read

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug responseSemantic proximity Read

A Pan-Cancer Single-Cell Compendium of Intratumoural HeterogeneitySemantic proximity Read

Single cell transcriptomics reveals molecular subtype and functional heterogeneity in models of breast cancerSemantic proximity Read

Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomicsSemantic proximity Read

Predicting drug response from single-cell expression profiles of tumoursSemantic proximity Read

A Multimodal Framework to Uncover Drug-Responsive Subpopulations in Triple-Negative Breast CancerSemantic proximity Read

Subclonal heterogeneity and evolution in breast cancerSemantic proximity Read

Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer SubtypesSemantic proximity Read

Deciphering Human Tumor Biology by Single-Cell Expression ProfilingSemantic proximity Read

A highly resolved integrated single-cell atlas of human breast cancersSemantic proximity Read