Article

Inferring therapeutic vulnerability within tumors through integration of pan-cancer cell line and single-cell transcriptomic profiles

2023-11-01

Abstract excerpt

Single-cell RNA sequencing greatly advanced our understanding of intratumoral heterogeneity through identifying tumor subpopulations with distinct biologies. However, translating biological differences into treatment strategies is challenging, as we still lack tools to facilitate efficient drug discovery that tackles heterogeneous tumors. One key component of such approaches tackles accurate prediction of drug res...

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Literature Corpus work: 9b49cf02-2abf-549f-8294-271abdfa0a1f
DOI: 10.1101/2023.10.29.564598

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