scDrugAtlas: an integrative single-cell drug response database for dissecting tumor heterogeneity in therapeutic efficacy

Abstract excerpt

Tumor heterogeneity often leads to substantial differences in responses to same drug treatment. The presence of pre-existing or acquired drug-resistant cell sub-populations within a tumor survive and proliferate, ultimately resulting in tumor relapse and metastasis. The drug resistance is the leading cause of failure in clinical tumor therapy. Therefore, accurate identification of drug-resistant tumor cell subpopu...

Topics

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• Algorithms
• Antineoplastic Agents
• Biomarkers, Tumor
• Carcinoma, Non-Small-Cell Lung
• Drug Resistance, Neoplasm
• Models, Theoretical
• Oligonucleotide Array Sequence Analysis
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

c036c3d2-0ac3-5b0a-a6d8-835e4c56c2ba

DOI

10.1101/2024.09.05.611403