Article

A free-running oscillator times and executes centriole biogenesis

2019-01-03

Abstract excerpt

The accurate timing of organelle biogenesis and the precise regulation of organelle size are crucial for cell physiology. Centriole biogenesis initiates exclusively in S-phase, when a daughter centriole emerges from the side of a pre-existing mother and grows until it reaches its mother’s size. This process is regulated by Polo-like kinase 4 (Plk4), which is recruited to centrioles in oscillatory waves in flies an...

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Literature Corpus work: d6240c06-5d43-51fb-9d59-61ee613228a9
DOI: 10.1101/510875

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