Article

Centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly

2021-10-26

Abstract excerpt

Mitotic centrosomes are formed when centrioles start to recruit large amounts of pericentriolar material (PCM) around themselves in preparation for mitosis. This centrosome “maturation” requires the centrioles and also Polo/PLK1 protein kinase. The PCM comprises several hundred proteins and, in Drosophila , Polo cooperates with the conserved centrosome proteins Spd-2/CEP192 and Cnn/CDK5RAP2 to assemble a PCM scaf...

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Literature Corpus work: 0d0243b9-7987-50db-a1b7-292f461fb571
DOI: 10.1101/2021.10.26.465695

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