Article
Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions.
Nature cell biology - 1 Apr 2026
He Shan, Lemma Linnea M, Martinez-Calvo Alejandro, He Guanhua, Hennacy Jessica H, Wang Lianyong, Ergun Sabrina L, Rai Ashwani K, Wang Colton, Bunday Luke, Kayser-Browne Angelo, Wang Quan, Brangwynne Clifford P, Wingreen Ned S, Jonikas Martin C
Abstract excerpt
Biomolecular condensates spatially organize cellular functions, but the regulation of their size, number, dissolution and re-condensation is poorly understood. The pyrenoid, an algal biomolecular condensate that mediates one-third of global CO2 fixation, typically exists as one large condensate per chloroplast, but during cell division it transiently dissolves and reconfigures into multiple smaller condensates....
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