Article

Clinically relevant mutations of mycobacterial GatCAB inform regulation of translational fidelity

2021-03-29

Abstract excerpt

Most bacteria employ a two-step indirect tRNA aminoacylation pathway for the synthesis of aminoacylated tRNA Gln and tRNA Asn . The heterotrimeric enzyme GatCAB performs a critical amidotransferase reaction in the second step of this pathway. We have previously demonstrated in mycobacteria that this two-step pathway is error-prone and translational errors contribute to adaptive phenotypes such as antibiotic tole...

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Literature Corpus work: d60a951e-a57c-5f21-9f5a-e515d8300564
DOI: 10.1101/2021.03.29.437598

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