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Article

Development of Assay Systems for Amber Codon Decoding at the Steps of Initiation and Elongation in Mycobacteria.

Journal of bacteriology - 15 Nov 2018

Govindan Ashwin, Miryala Sandeep, Mondal Sanjay, Varshney Umesh

Abstract excerpt

Genetic analysis of the mechanism of protein synthesis in Gram-positive bacteria has remained largely unexplored because of the unavailability of appropriate in vivo assay systems. We developed chloramphenicol acetyltransferase (CAT)-based in vivo reporter systems to study translation initiation and elongation in Mycobacterium smegmatis The CAT reporters utilize specific decoding of amber codons by mutant...

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Identifiers

PMID: 30181124
DOI: 10.1128/JB.00372-18
PMCID: PMC6199473

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