Article

Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria

2023-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Each genome encodes some codons more frequently than their synonyms (codon usage bias), but codons are also arranged more frequently into specific pairs (codon pair bias). Recoding viral genomes and yeast or bacterial genes with non-optimal codon pairs has been shown to decrease gene expression. Gene expression is thus importantly regulated not only by the use of particular codons but by their p...

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Literature Corpus work: ff3b7c5d-1a57-5d72-b3c4-c8f9bde75474
DOI: 10.1101/2023.03.17.532606

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