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Nucleotidyltransferase toxin MenT targets and extends the aminoacyl acceptor ends of serine tRNAs <i>in vivo</i> to control <i>Mycobacterium tuberculosis</i> growth

2024-03-07

Abstract excerpt

<h4>ABSTRACT</h4> Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth and represent attractive therapeutic targets to fight pathogens. In this study, we characterized the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis , the bacterium responsible for human tuberculosis in humans. We show that MenT3 is a robust cytidine specific tRNA nucleotidyltransferase in vitr...

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Literature Corpus work
19903c38-3ae0-5727-bc8b-e5cf205b92d0
DOI
10.1101/2024.03.07.583660
Open publication

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Nucleotidyltransferase toxin MenT targets and extends the aminoacyl acceptor ends of serine tRNAs <i>in vivo</i> to control <i>Mycobacterium tuberculosis</i> growthDOI 10.1101/2024.03.07.583660
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