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Article

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).

The Journal of biological chemistry - 22 Jun 2018

Ahangar Mohd Syed, Furze Christopher M, Guy Collette S, Cooper Charlotte, Maskew Kathryn S, Graham Ben, Cameron Alexander D, Fullam Elizabeth

Abstract excerpt

The Mycobacterium tuberculosis (Mtb) pathogen encodes a GlcNAc-6-phosphate deacetylase enzyme, NagA (Rv3332), that belongs to the amidohydrolase superfamily. NagA enzymes catalyze the deacetylation of GlcNAc-6-phosphate (GlcNAc6P) to glucosamine-6-phosphate (GlcN6P). NagA is a potential antitubercular drug target because it represents the key enzymatic step in the generation of essential amino-sugar precursors...

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Identifiers

PMID: 29728457
DOI: 10.1074/jbc.RA118.002597
PMCID: PMC6016474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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