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Article

Indirect tRNA aminoacylation during accurate translation and phenotypic mistranslation.

Current opinion in chemical biology - 1 Dec 2017

Rathnayake Udumbara M, Wood Whitney N, Hendrickson Tamara L

Abstract excerpt

The fact that most bacteria do not contain a full set of aminoacyl-tRNA synthetases (aaRS) is often underappreciated. In the absence of asparaginyl-tRNA and/or glutaminyl-tRNA synthetase (AsnRS and GlnRS), Asn-tRNAAsn and/or Gln-tRNAGln are produced by an indirect tRNA aminoacylation pathway that relies on misacylation of these two tRNAs by two different misacylating aaRSs, followed by transamidation by an...

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Identifiers

PMID: 29156229
DOI: 10.1016/j.cbpa.2017.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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