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Article

Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity.

mBio - 31 Aug 2021

Li Yang-Yang, Cai Rong-Jun, Yang Jia-Ying, Hendrickson Tamara L, Xiang Ye, Javid Babak

Abstract excerpt

Most bacteria employ a two-step indirect tRNA aminoacylation pathway for the synthesis of aminoacylated tRNAGln and tRNAAsn. The heterotrimeric enzyme GatCAB performs a critical amidotransferase reaction in the second step of this pathway. We have previously demonstrated in mycobacteria that this two-step pathway is error prone and translational errors contribute to adaptive phenotypes such as antibiotic...

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Identifiers

PMID: 34225495
DOI: 10.1128/mBio.01100-21
PMCID: PMC8406222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity.PMID 34225495Read ↗

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