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Article

Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance.

The Journal of biological chemistry - 27 Oct 2006

Ortiz Pedro A, Ulloque Rory, Kihara George K, Zheng Haiyan, Kinzy Terri Goss

Abstract excerpt

Eukaryotic elongation factor 2 (eEF2) mediates translocation in protein synthesis. The molecular mimicry model proposes that the tip of domain IV mimics the anticodon loop of tRNA. His-699 in this region is post-translationally modified to diphthamide, the target for Corynebacterium diphtheriae and Pseudomonas aeruginosa toxins. ADP-ribosylation by these toxins inhibits eEF2 function causing cell death....

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Share to Anticodon
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

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Share to Peptide Chain Elongation, Translational

Share to Protein Biosynthesis

Share to RNA, Transfer

Share to Sequence Analysis, Protein

Source

Identifiers

PMID: 16950777
DOI: 10.1074/jbc.M607076200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance.PMID 16950777Read ↗

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