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Endocytosis at the mouse blood brain barrier is elevated during sleep

2026-04-03

Abstract excerpt

Sleep is thought to be important for the clearance of brain waste, but exactly how it does so is still debated. Here, we demonstrate that endocytosis in brain endothelial cells (BECs) of the blood–brain barrier (BBB) is enhanced during sleep, facilitating the removal of brain-derived waste, including amyloid-β, into the circulation. Using proteomics, in vivo tracer imaging, and endothelial-specific genetic perturb...

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Literature Corpus work
d5b32316-d5c7-5fd6-b7e4-3b85b36dbf93
DOI
10.64898/2026.04.02.716170
Open publication

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Endocytosis at the mouse blood brain barrier is elevated during sleepDOI 10.64898/2026.04.02.716170
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