Article

Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies

2024-12-27

Abstract excerpt

<title>Abstract</title> GBA is the major risk gene for Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB), two common α-synucleinopathies with cognitive deficits. We investigated the role of mutant GBA in cognitive decline by utilizing Gba (L444P) mutant, SNCA transgenic (tg), and Gba-SNCA double mutant mice. Notably, Gba mutant mice showed early cognitive deficits but lacked PD-like motor deficits o...

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Literature Corpus work: 89e03c84-06b0-58f4-a3e8-c72f967216c9
DOI: 10.21203/rs.3.rs-5649173/v1

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