Back to search

Article

A novel technique for monitoring Alzheimer’s disease associated changes in brain-derived extracellular vesicle cargos in mouse models

2026-03-17

Abstract excerpt

Extracellular vesicles (EVs) are critical mediators of intercellular communication, carrying molecular cargos such as small noncoding RNAs (ncRNAs) that reflect the physiological and pathological state of their cells of origin. However, studying brain-derived EVs has been challenging due to the blood-brain barrier. Here, we optimized and validated an open-flow microdialysis (OFM) protocol for sampling EVs directly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
76b2718f-539d-5e60-b7a2-a8dd509125aa
DOI
10.64898/2026.03.13.711599
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A novel technique for monitoring Alzheimer’s disease associated changes in brain-derived extracellular vesicle cargos in mouse modelsDOI 10.64898/2026.03.13.711599
Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EV-ISF) reveals sex-dependent changes in microglial EV proteome in response to Aβ pathologySemantic proximity
Relationships of Alzheimer’s disease and apolipoprotein E genotypes with small RNA and protein cargo of brain tissue extracellular vesiclesSemantic proximity
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative diseaseSemantic proximity
Biomarker Organization in Circulating Extracellular Vesicles: New Applications in Detecting Neurodegenerative DiseasesSemantic proximity
Insights Into the Proteomic Profiling of Extracellular Vesicles for the Identification of Early Biomarkers of NeurodegenerationSemantic proximity
An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer's disease.Semantic proximity
Integration of transcriptional signatures from brain tissue and plasma extracellular vesicles of a preclinical tauopathy mouse modelSemantic proximity
Molecular and Structural Characterization Reveals Divergent Extracellular Vesicle Profiles Between Wild Type and Alzheimer’s Disease Cerebrocortical OrganoidsSemantic proximity
Enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from Alzheimer’s disease mouse modelSemantic proximity
Extracellular Vesicles as Mediators of Intercellular Communication: Implications for Drug Discovery and Targeted TherapiesSemantic proximity
Long Non-coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer’s DiseaseSemantic proximity
Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.