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Article

Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability.

Cell reports - 6 Jul 2021

Cui Yaxiong, Wang Yanxiao, Song Xiaopeng, Ning Huimin, Zhang Yizhe, Teng Yan, Wang Jun, Yang Xiao

Abstract excerpt

The low level of transcytosis is a unique feature of cerebrovascular endothelial cells (ECs), ensuring restrictive blood-brain barrier (BBB) permeability. Major facilitator superfamily domain-containing 2a (MFSD2A) is a key regulator of the BBB function by suppressing caveolae-mediated transcytosis. However, the mechanisms regulating MFSD2A at the BBB have been barely explored. Here, we show that cerebrovascular...

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Identifiers

PMID: 34233198
DOI: 10.1016/j.celrep.2021.109327

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