Article

BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes

2025-12-17

Abstract excerpt

In a healthy brain, astrocytes maintain neuronal homeostasis by removing proteins like tau from the extracellular space, preventing their uptake by neurons. In Alzheimer’s disease (AD), this function is impaired, contributing to tau accumulation. Many AD risk genes are linked to endocytosis pathways, suggesting their role in AD pathogenesis. Astrocytes can internalize, degrade, and release tau, but the mechanisms...

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Literature Corpus work: 35c57df0-0018-5b97-a231-d9f453020941
DOI: 10.64898/2025.12.17.694879

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