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Article

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Aug 2016

Dinkins Michael B, Enasko John, Hernandez Caterina, Wang Guanghu, Kong Jina, Helwa Inas, Liu Yutao, Terry Alvin V, Bieberich Erhard

Abstract excerpt

UNLABELLED: Recent evidence implicates exosomes in the aggregation of Aβ and spreading of tau in Alzheimer's disease. In neural cells, exosome formation can be blocked by inhibition or silencing of neutral sphingomyelinase-2 (nSMase2). We generated genetically nSMase2-deficient 5XFAD mice (fro;5XFAD) to assess AD-related pathology in a mouse model with consistently reduced ceramide generation. We conducted in...

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Identifiers

PMID: 27535912
DOI: 10.1523/JNEUROSCI.1429-16.2016
PMCID: PMC4987436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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