Article

Redox Regulation of LAT Enhances T Cell-Mediated Inflammation

2024-03-08

Abstract excerpt

The positional cloning of single nucleotide polymorphisms (SNPs) of the neutrophil cytosolic factor 1 (Ncf1) gene, advocating that a low oxidative burst drives autoimmune disease, demands an understanding of the underlying molecular causes. A cellular target could be T cells, which have been shown to be regulated by reactive oxygen species (ROS). However, the pathways by which ROS mediate T cell signaling remain u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5ac1b0f-d753-585c-be9d-4b63edb2b19e
DOI: 10.20944/preprints202403.0506.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Redox Regulation of LAT Enhances T Cell-Mediated InflammationDOI 10.20944/preprints202403.0506.v1Read

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species.Semantic proximity Read

LAT encodes T cell activation pathway balanceSemantic proximity Read

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammationSemantic proximity Read

Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.Semantic proximity Read

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Semantic proximity Read

ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease developmentSemantic proximity Read

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Semantic proximity Read

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read

Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.Semantic proximity Read

B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.Semantic proximity Read

Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain.Semantic proximity Read