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Article

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species.

The Journal of clinical investigation - 1 Oct 2007

Gelderman Kyra A, Hultqvist Malin, Pizzolla Angela, Zhao Ming, Nandakumar Kutty Selva, Mattsson Ragnar, Holmdahl Rikard

Abstract excerpt

Reduced capacity to produce ROS increases the severity of T cell-dependent arthritis in both mice and rats with polymorphisms in neutrophil cytosolic factor 1 (Ncf1) (p47phox). Since T cells cannot exert oxidative burst, we hypothesized that T cell responsiveness is downregulated by ROS produced by APCs. Macrophages have the highest burst capacity among APCs, so to study the effect of macrophage ROS on T cell...

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Identifiers

PMID: 17909630
DOI: 10.1172/JCI31935
PMCID: PMC1994618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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