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Article

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2015

Siggs Owen M, Miosge Lisa A, Daley Stephen R, Asquith Kelly, Foster Paul S, Liston Adrian, Goodnow Christopher C

Abstract excerpt

Gene variants that disrupt TCR signaling can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune pathology. Null mutations of the gene encoding the scaffold protein Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76), for example, cause an arrest of T cell positive selection, whereas a synthetic membrane-targeted allele allows limited positive...

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Identifiers

PMID: 25662996
DOI: 10.4049/jimmunol.1400326
PMCID: PMC4355390

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