Article
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.
The Journal of experimental medicine - 4 Apr 2005
Sommers Connie L, Lee Jan, Steiner Kevin L, Gurson Jordan M, Depersis Corinne L, El-Khoury Dalal, Fuller Claudette L, Shores Elizabeth W, Love Paul E, Samelson Lawrence E
Abstract excerpt
Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function. A mutation of LAT (Y136F) that disrupts phospholipase C-gamma1 activation and subsequent calcium influx causes a partial block in T cell development and leads to a severe lymphoproliferative disease in homozygous knock-in mice. One possible contribution to the fatal disease of LAT Y136F...
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