Article

LAT encodes T cell activation pathway balance

2024-08-26

Abstract excerpt

Immune cells transduce environmental stimuli into responses essential for host health via complex signaling cascades. T cells, in particular, leverage their unique T cell receptors (TCRs) to detect specific Human Leukocyte Antigen (HLA)-presented peptides. TCR activation is then relayed via linker for activation of T cells (LAT), a TCR-proximal disordered adapter protein, which organizes protein partners and media...

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Literature Corpus work: 2d674317-04c6-533d-b954-1c2610d37045
DOI: 10.1101/2024.08.26.609683

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