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Article

Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2007

Hultqvist Malin, Bäcklund Johan, Bauer Kristin, Gelderman Kyra A, Holmdahl Rikard

Abstract excerpt

The view on reactive oxygen species (ROS) in inflammation is currently shifting from being considered damaging toward having a more complex role in regulating inflammatory reactions. We recently demonstrated a role of ROS in regulation of animal models for the autoimmune disease rheumatoid arthritis. Low levels of ROS production, due to a mutation in the Ncf1 gene coding for the Ncf1 (alias p47(phox)) subunit of...

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Source

Identifiers

PMID: 17641008
DOI: 10.4049/jimmunol.179.3.1431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.PMID 17641008Read ↗

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