Article
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
Immunity - 21 Aug 2009
Mingueneau Michael, Roncagalli Romain, Grégoire Claude, Kissenpfennig Adrien, Miazek Arkadiusz, Archambaud Cristel, Wang Ying, Perrin Pierre, Bertosio Elodie, Sansoni Amandine, Richelme Sylvie, Locksley Richard M, Aguado Enrique, Malissen Marie, Malissen Bernard
Abstract excerpt
Despite compromised T cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of the adaptor linker for activation of T cells (LAT) was constitutively mutated (Lat(Y136F) mice) accumulate CD4(+) T cells that trigger autoimmunity and inflammation. Here we show that equipping postthymic C...
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