Article
Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.
Frontiers in immunology - 1 Jan 2021
Li Mengyao, Zhang Wentao, Zhang Jing, Li Xiaowei, Zhang Fujun, Zhu Wenhua, Meng Liesu, Holmdahl Rikard, Lu Shemin
Abstract excerpt
Neutrophil cytosolic factor 1 (Ncf1) is a major genetic factor associated with autoimmune diseases and has been identified as a key player in autoimmune mediated inflammation. We addressed the role of Ncf1 in an antigen-induced pulmonary inflammation model, and found that the Ncf1m1j mutation, causing a deficient reactive oxygen species response, alleviated disease. The Ncf1m1j mutation was associated with a...
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