Article

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

2021-12-06

Abstract excerpt

Chronic autoimmune diseases are associated with mutations in PTPN22, a modifier of T cell receptor signaling. As with all protein tyrosine phosphatases the activity of PTPN22 is redox regulated, but if or how such regulation can modulate inflammatory pathways in vivo is not known. To determine this, we created a mouse with a cysteine-to-serine mutation at position 129 in PTPN22 (C129S), a residue proposed to alte...

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Literature Corpus work: d7249b15-adb7-507b-a5b8-fea7831296bf
DOI: 10.1101/2021.12.02.470976

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