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Article

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.

Immunological reviews - 1 Jan 2016

Holmdahl Rikard, Sareila Outi, Olsson Lina M, Bäckdahl Liselotte, Wing Kajsa

Abstract excerpt

The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced reactive oxygen species (ROS) is based on a genetic search for the major genes controlling autoimmune inflammatory disorders. Surprisingly, the disease-promoting allele determined a lower ROS response and was therefore in complete contrast to the prevailing dogma. Once cloned, it opened the possibility to dissect this complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26683156
DOI: 10.1111/imr.12378

Genes

NCF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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