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Article

B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.

European journal of immunology - 1 Aug 2015

Khmaladze Ia, Saxena Amit, Nandakumar Kutty Selva, Holmdahl Rikard

Abstract excerpt

Autoantibody-mediated inflammation contributes to the development of rheumatoid arthritis (RA), and anti-type II collagen (CII) antibodies are present in the serum, synovial fluid, and cartilage of RA patients. We had previously generated and characterized knock-in mice expressing a germline-encoded, CII-specific IgH (B10Q.ACB), which demonstrated positive selection of self-reactive B cells. Here, we show that...

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Identifiers

PMID: 25989352
DOI: 10.1002/eji.201545518

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