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A multi-enhancer hub at the <i>Ets1</i> locus controls T cell differentiation and allergic inflammation through 3D genome topology

2022-10-28

Abstract excerpt

Multi-enhancer hubs are spatial clusters of enhancers which have been recently characterized across numerous developmental programs. Yet, the functional relevance of these three-dimensional (3D) structures is poorly understood. Here we show that the multiplicity of enhancers interacting with the transcription factor Ets1 is essential to control the precise expression level of this gene in response to cellular cue...

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Literature Corpus work
d59fda40-45cf-5f12-b2dd-611c55b210dd
DOI
10.1101/2022.10.28.514213
Open publication

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A multi-enhancer hub at the <i>Ets1</i> locus controls T cell differentiation and allergic inflammation through 3D genome topologyDOI 10.1101/2022.10.28.514213
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