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Dissecting super-enhancer hierarchy based on chromatin interactions

2017-06-13

Abstract excerpt

Recent studies have highlighted super-enhancers (SEs) as important regulatory elements for gene expression, but their intrinsic properties remain incompletely characterized. Through an integrative analysis of Hi-C and ChIP-seq data, we find that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers. Hub enhancers share similar histone marks with non-hub enhancers, bu...

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Literature Corpus work
f7a3f463-e753-59a4-a795-17d05c57f61e
DOI
10.1101/149583
Open publication

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Dissecting super-enhancer hierarchy based on chromatin interactionsDOI 10.1101/149583
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