Article

Pervasive <i>cis</i> -regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system

2025-12-25

Abstract excerpt

Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell development is less characterized. Here, we analyzed hundreds of chromatin accessibility, gene expression, transcription factor occupancy and DNA-DNA contact datasets in diverse mouse and human immune cells. We identi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8dfd707c-6767-56e3-a433-464bf837322f
DOI: 10.64898/2025.12.22.696042

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pervasive <i>cis</i> -regulatory co-option of a transposable element family reinforces cell identity across the mouse immune systemDOI 10.64898/2025.12.22.696042Read

Regulatory Transposable Elements in the Encyclopedia of DNA ElementsSemantic proximity Read

Transposable elements regulate thymus development and functionSemantic proximity Read

What Doesn't Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation.Semantic proximity Read

Unraveling transposable element-mediated regulatory landscape in diverse human immune cellsSemantic proximity Read

Intrinsically linked lineage specificity of transposable elements, lncRNA genes, and transcriptional regulationSemantic proximity Read

Co-opted transposons help perpetuate conserved higher-order chromosomal structuresSemantic proximity Read

Atlas and developmental dynamics of mouse DNase I hypersensitive sitesSemantic proximity Read

Transposable elements drive species-specific and tissue-specific transcriptomes in human developmentSemantic proximity Read

Transposable elements generate regulatory novelty in a tissue-specific fashionSemantic proximity Read

Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re-Visiting the "Gene-Battery" Model.Semantic proximity Read

Transposable elements as a possible missing link between genetic predisposition and environmental triggers of autoimmune disorders: insights from type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis.Semantic proximity Read

Joint analysis of human retroelements-linked histone modification profiles reveals quickly evolving molecular processes connected with cancerSemantic proximity Read