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Article

Dissecting super-enhancer hierarchy based on chromatin interactions.

Nature communications - 5 Mar 2018

Huang Jialiang, Li Kailong, Cai Wenqing, Liu Xin, Zhang Yuannyu, Orkin Stuart H, Xu Jian, Yuan Guo-Cheng

Abstract excerpt

Recent studies have highlighted super-enhancers (SEs) as important regulatory elements for gene expression, but their intrinsic properties remain incompletely characterized. Through an integrative analysis of Hi-C and ChIP-seq data, here we find that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers. Hub enhancers share similar histone marks with non-hub...

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PMID: 29507293
DOI: 10.1038/s41467-018-03279-9
PMCID: PMC5838163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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