Article
A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease.
BMC genomics - 2 Nov 2020
Sethi Siddharth, Vorontsov Ilya E, Kulakovskiy Ivan V, Greenaway Simon, Williams John, Makeev Vsevolod J, Brown Steve D M, Simon Michelle M, Mallon Ann-Marie
Abstract excerpt
BACKGROUND: Efforts to elucidate the function of enhancers in vivo are underway but their vast numbers alongside differing enhancer architectures make it difficult to determine their impact on gene activity. By systematically annotating multiple mouse tissues with super- and typical-enhancers, we have explored their relationship with gene function and phenotype. RESULTS: Though super-enhancers drive high total-...
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