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A microprotein encoded by <i>FERMT3</i> modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

2025-12-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Human endothelial cells express numerous microproteins (miPs) encoded by small open reading frames (smORFs) distributed throughout the genome, yet the biological functions of most remain unknown. This study set out to characterize a novel 69 amino acid miP encoded by a smORF located within the coding sequence of the FERM domain containing kindlin-3 transcript (miP-FERMT3). <...

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Literature Corpus work
54d7c9e2-f270-56f5-9368-40fc3d745eb7
DOI
10.64898/2025.12.03.692074
Open publication

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A microprotein encoded by <i>FERMT3</i> modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescenceDOI 10.64898/2025.12.03.692074
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